Beyond sentinel node algorithm. Toward a more tailored surgery for cervical cancer patients
Identifieur interne : 001362 ( Main/Exploration ); précédent : 001361; suivant : 001363Beyond sentinel node algorithm. Toward a more tailored surgery for cervical cancer patients
Auteurs : Anna Fagotti ; Luigi Pedone Anchora ; Carmine Conte ; Vito Chiantera ; Enrico Vizza ; Lucia Tortorella ; Daniela Surico ; Pierandrea De Iaco ; Giacomo Corrado ; Francesco Fanfani ; Valerio Gallotta ; Giovanni ScambiaSource :
- Cancer Medicine [ 2045-7634 ] ; 2016.
Abstract
Nowadays cervical cancer is frequently diagnosed at early stage. For these patients lymph node metastasis (
Url:
DOI: 10.1002/cam4.722
PubMed: 27230108
PubMed Central: 4971900
Affiliations:
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Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Beyond sentinel node algorithm. Toward a more tailored surgery for cervical cancer patients</title>
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p>Nowadays cervical cancer is frequently diagnosed at early stage. For these patients lymph node metastasis (<styled-content style="fixed-case">LNM</styled-content>
) is considered the most important prognostic factor. During the last decade many efforts have been made to reduce rate of complications associated with lymphadenectomy (<styled-content style="fixed-case">LND</styled-content>
). A great interest has arisen in sentinel lymph node (<styled-content style="fixed-case">SLN</styled-content>
) biopsy as a technique able to decrease number of <styled-content style="fixed-case">LND</styled-content>
performed and, at the same time, to assess lymph nodal status. High diagnostic performances have been reached thanks to <styled-content style="fixed-case">SLN</styled-content>
surgical algorithm. However, despite the efforts, about 25% of these patients undergo at least unilateral <styled-content style="fixed-case">LND</styled-content>
to meet <styled-content style="fixed-case">NCCN</styled-content>
recommendations. Data of women with International Federation of Gynecology and Obstetrics stage <styled-content style="fixed-case">IA</styled-content>
1‐<styled-content style="fixed-case">IB</styled-content>
1/<styled-content style="fixed-case">IIA</styled-content>
1 cervical carcinoma were retrospectively collected by six Italian institutions. All patients underwent complete preoperative staging workup and were primarily treated by radical hysterectomy and pelvic bilateral <styled-content style="fixed-case">LND</styled-content>
. A total of 368 patients with early‐stage cervical cancer were identified. Among them 333 (90.5%) showed no suspicious enlarged nodes at the preoperative magnetic resonance imaging (<styled-content style="fixed-case">MRI</styled-content>
). In this subset, tumor diameter ≥20 mm was the only independent predictor of <styled-content style="fixed-case">LN</styled-content>
status (<italic>P</italic>
= 0.003). None of the 106 patients with negative <styled-content style="fixed-case">MRI</styled-content>
nodal assessment, with squamous and adenosquamous histotype and a tumor diameter less than 2 cm had <styled-content style="fixed-case">LNM</styled-content>
. Based on these results we propose a new modified <styled-content style="fixed-case">SLN</styled-content>
surgical algorithm that could safely reduce <styled-content style="fixed-case">LND</styled-content>
performed in patients with very low‐risk early‐stage cervical cancer.</p>
</div>
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<tree><noCountry><name sortKey="Chiantera, Vito" sort="Chiantera, Vito" uniqKey="Chiantera V" first="Vito" last="Chiantera">Vito Chiantera</name>
<name sortKey="Conte, Carmine" sort="Conte, Carmine" uniqKey="Conte C" first="Carmine" last="Conte">Carmine Conte</name>
<name sortKey="Corrado, Giacomo" sort="Corrado, Giacomo" uniqKey="Corrado G" first="Giacomo" last="Corrado">Giacomo Corrado</name>
<name sortKey="De Iaco, Pierandrea" sort="De Iaco, Pierandrea" uniqKey="De Iaco P" first="Pierandrea" last="De Iaco">Pierandrea De Iaco</name>
<name sortKey="Fagotti, Anna" sort="Fagotti, Anna" uniqKey="Fagotti A" first="Anna" last="Fagotti">Anna Fagotti</name>
<name sortKey="Fanfani, Francesco" sort="Fanfani, Francesco" uniqKey="Fanfani F" first="Francesco" last="Fanfani">Francesco Fanfani</name>
<name sortKey="Gallotta, Valerio" sort="Gallotta, Valerio" uniqKey="Gallotta V" first="Valerio" last="Gallotta">Valerio Gallotta</name>
<name sortKey="Pedone Anchora, Luigi" sort="Pedone Anchora, Luigi" uniqKey="Pedone Anchora L" first="Luigi" last="Pedone Anchora">Luigi Pedone Anchora</name>
<name sortKey="Scambia, Giovanni" sort="Scambia, Giovanni" uniqKey="Scambia G" first="Giovanni" last="Scambia">Giovanni Scambia</name>
<name sortKey="Surico, Daniela" sort="Surico, Daniela" uniqKey="Surico D" first="Daniela" last="Surico">Daniela Surico</name>
<name sortKey="Tortorella, Lucia" sort="Tortorella, Lucia" uniqKey="Tortorella L" first="Lucia" last="Tortorella">Lucia Tortorella</name>
<name sortKey="Vizza, Enrico" sort="Vizza, Enrico" uniqKey="Vizza E" first="Enrico" last="Vizza">Enrico Vizza</name>
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